Microneedling is a revolutionary and novel therapeutic modality that has been widely utilized in dermatology, aesthetic and rejuvenative medicine. Also known as collagen induction therapy, microneedling involves the repetitive puncturing of the skin using specially curated and sterilized microneedles. Microneedling has seen merits in the reversal of the signs of aging – particularly for wrinkles, scarring and the general appearance of the skin, conferring a youthful exuberance upon it.



Dermapen 4 is an exciting breakthrough in the future of microneedling. This device sets a new standard and benchmark that delivers the ultimate in advanced and innovative microneedling with unsurpassed confidence, service and outstanding patient results. Dermapen 4 is far the less painful microneedling device in the market. We don’t recommend Numbing cream, because it is so comfortable! and if your Dermapen Provider uses our CORRECT Dermapenworld protocols and aftercare (ie the DP Dermaceuticals HylaActive Masks) the treatment is over before you know it.

If you are not sure if you feel comfortable not using numbing cream, have a read below at all information regards to Topical Local Anaesthetic (TLA). And when you feel ready to book an appointment to undergo your Dermapen treatment, click here to find an Authorized Treatment Provider close to you




The Role of TLA

Topical local anaesthetic (TLA) is a form of therapy which leads to a superficial loss of sensation over the skin where it is directly applied. Unlike local anaesthesia, TLA does not require painful injections and is topically administered on the skin via a spray, gel, lotion, cream or ointment. TLA works by reversibly blocking the nerve conduction of the nerve cells within the dermis of the skin. TLA disrupts the nerve cell permeability to sodium, decreasing depolarization and subsequently impeding the nerve cell’s ability to generate an action potential.

Although TLA has merits in the field of healthcare – from pain relief in children who require blood tests, to numbing the eyes during the removal of a foreign body and numbing the gums during dental procedures, it is not bereft of adverse effects.


Adverse Effects of TLA


TLA has been reported to cause burning or stinging at the site of administration, and can even lead to systemic toxicity if used in excess. Signs of systemic toxicity include agitation, elevated blood pressure, heart rhythm disturbances and muscle twitching. TLA may also lead to a localized allergic reaction or a widespread anaphylaxis which can be fatal. These adverse effects underscore the importance of the judicious and careful use of TLA.


Is TLA essential in Microneedling?


Although many aesthetic and rejuvenative medical clinics advocate for the use of TLA during microneedling in order to maximise patient comfort and ensure a completely pain-free experience, the available evidence does not support its role in maximising the effectiveness of the procedure. Indeed, a recent study in 2017 showed that microneedling in patients with stretch marks was safe and effective without TLA. The researchers even biopsied the target skin areas and found that there was an increased quality and quantity of collagen and elastin fibres. Although TLA was not used, patients still tolerated the procedure well.

In fact, this observation is not just limited to the facial skin. Another study in 2014 showed that microneedling in the area of scalp for hair loss resulted in significant improvement without the use of TLA, further supporting the notion that TLA simply does not improve the efficacy of microneedling.


Microneedling – To Numb or Not To Numb image by Dermapen World


How does TLA impact Collagen Synthesis?


Studies show that TLA may even hinder the proliferation and synthesis of collagen. In 2017, researchers from the University of Washington found that lidocaine and mepivacaine – commonly used local anaesthetics, inhibited processes relevant to the repair of the skin in human skin fibroblasts (specialized cells which produce and deposit collagen).

In conclusion, although TLA may ensure a completely pain-free procedure, it is associated with a bevy of potentially hazardous side-effects, does not improve the efficacy of microneedling and may even negatively impact upon the results.


If you feel ready to undergo your Dermapen treatment, find here an Authorized Treatment Provider close to you.



1.Iriarte, C., et al., Review of applications of microneedling in dermatology. Clinical, cosmetic and investigational dermatology, 2017. 10 : p. 289-298.

2.Kumar, M., R. Chawla, and M. Goyal, Topical anesthesia. Journal of anaesthesiology, clinical pharmacology, 2015. 31(4): p. 450-456.

3.Casabona, G. and P. Marchese, Calcium Hydroxylapatite Combined with Microneedling and Ascorbic Acid is Effective for Treating Stretch Marks. Plastic and reconstructive surgery. Global open, 2017. 5(9): p. e1474-e1474.

4.Chandrashekar, B., V. Yepuri, and V. Mysore, Alopecia areata-successful outcome with microneedling and triamcinolone acetonide. Journal of cutaneous and aesthetic surgery, 2014. 7(1): p. 63-64.

5.Bentov, I., et al., Lidocaine Impairs Proliferative and Biosynthetic Functions of Aged Human Dermal Fibroblasts. Anesthesia and analgesia, 2016. 123(3): p. 616-623.